Mycoplasma bovis – herd diagnostics and epidemiological knowledge to prevent infections in Swedish cattle

Mycoplasma bovis is considered an emerging bacterial pathogen that causes severe disease in cattle, e.g. mastitis, pneumonia, polyarthritis and otitis media. Infections are often chronic and poorly responsive to treatment, compromising animal welfare. Antibiotic treatments can increase dramatically in infected herds, increasing the selection for antimicrobial resistance. The prevalence in Swedish cattle herds is lower than in many other European countries, but preliminary data suggest that it is increasing. The overall aim of the project is to obtain knowledge on epidemiology and efficient diagnostic methods to prevent transmission of M bovis to uninfected cattle herds.

In this project we will investigate the prevalence of M bovis infection and the regional distribution over time. Diagnostic methods and sampling strategy for identification of infected vs. free herds will be evaluated. Duration of infection and antibody responses in individual animals will be explored, along with effects on health and risk factors for infection related to management. We will use whole genome sequencing of isolates to study transmission routes between herds and regions. Sequences will also be explored for mutations indicating antimicrobial resistance. Correct identification of infected animals will aid in early recognition of M bovis infection by farmers and veterinarians. The project will also increase the awareness among farmers and advisors of the importance of good biosecurity measures.